Publications

(For a complete listing, see Google Scholar or NCBI.)

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM (2024) RBM43 controls PGC1⍺ translation and a PGC1⍺-STING signaling axis. Cell Metabolism, in press.

Herrera-Melle L, Cicuéndez B, López JA, Dumesic PA, Wilensky SE, Rodríguez E, Leiva-Vega L, Caballero A, León M, Vázquez, Spiegelman BM, Folgueira C, Mora A, Sabio G (2024) p38⍺ kinase governs muscle strength through PGC1⍺ in mice. Acta Physiologica 240:e14234.

Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G (2024) Remodeling p38 signaling in muscle controls locomotor activity via IL-15. Science Advances 10:eadn5993.

Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer S, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma A, Balaz M, Wolfrum C, Spiegelman BM (2024) Development of a functional beige fat cell line: evidence for independent subclasses of cells expressing UCP1 and the futile creatine cycle. Cell Metabolism 36:2130-2145.

Saavedra P, Dumesic PA, Hu Y, Jouandin P, Binari R, Wilensky SE, Filine E, Rodiger J, Wang H, Spiegelman BM, Perrimon N (2023) REPTOR/CREBRF encode key regulators of muscle energy metabolism. Nature Communications 14:4943.

Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger H, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM (2023) Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metabolism 35:535-549.

Jannig PR*, Dumesic PA*, Spiegelman BM*, Ruas JL* (2022) SnapShot: Regulation and biology of PGC-1⍺. Cell 185:1444.

Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millan JL, Chouchani ET, Kazak L, Spiegelman BM (2021) Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature 593:580-585.

Leung KL, Sanchita S, Pham CT, Davis BA, Okhovat M, Ding X, Dumesic PA, Grogan TR, Williams KJ, Morselli M, Ma F, Carbone L, Li X, Pellegrini M, Dumesic DA, Chazenbalk GD (2020) Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular reprogramming. Clinical Epigenetics 12:181.

Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD (2020) ATP hydrolysis by the SNF2 domain of Dnmt5 is coupled to both specific recognition and modification of hemimethylated DNA. Molecular Cell 79:127-139.

Catania S, Dumesic PA*, Pimentel H*, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Linter R, Yates JR III, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD (2020) Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase. Cell 180:263-277.

Dumesic PA*, Egan DF*, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM (2019) An evolutionarily conserved uORF regulates PGC1α and oxidative metabolism in mice, flies, and bluefin tuna. Cell Metabolism 30:190-200.

Clarke SC, Dumesic PA, Homer CM, O’Donoghue AJ, Pallova L, Majer P, Madhani HD, Craik CS (2015) Integrated activity and genetic profiling of secreted peptidases in Cryptococcus neoformans reveals an aspartyl peptidase required for low pH survival and virulence. PLoS Pathogens 12:e1006051.

Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR III, Madhani HD (2015) Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Research 43:9017-9027.

Dumesic PA, Homer CM, Moresco J, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR III, Madhani HD (2015) Product binding enforces the genomic specificity of a yeast Polycomb repressive complex. Cell 160:204-218.

Dumesic PA, Madhani HD (2014) Recognizing the enemy within: licensing RNA-guided genome defense. Trends in Biochemical Sciences 39:25-34.

Dumesic PA, Madhani HD (2013) The spliceosome as a transposon sensor. RNA Biology 10:1653-1660.

Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR III, Bartel DP, Madhani HD (2013) Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell 152:957-968.

Rougemaille M, Braun S*, Coyle S*, Dumesic PA*, Garcia JF*, Isaac RS*, Libri D, Narlikar GJ, Madhani HD (2012) Ers1 links HP1 to RNAi. Proceedings of the National Academy of Sciences USA 109:11258-11263.

Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD (2010) Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions. Genes and Development 24:1758-1771.

Dumesic PA, Scholl FA, Barragan DI, Khavari PA (2009) Erk1/2 MAP kinases are required for epidermal G2/M progression. Journal of Cell Biology 185:409-422.

Scholl FA, Dumesic PA, Barragan DI, Harada K, Charron J, Khavari PA (2009) Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia. Cancer Research 69:3772-3778.

Scholl FA, Dumesic PA, Barragan DI, Charon J, Khavari PA (2009) Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin. Oncogene 28:1485-1495.

Scholl FA, Dumesic PA, Barragan DI, Harada K, Bissonauth V, Charron J, Khavari PA (2007) Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Developmental Cell 12:615-629.

Scholl FA, Dumesic PA, Khavari PA (2005) Effects of active MEK1 expression in vivo. Cancer Letters 230:1-5.

Scholl FA, Dumesic PA, Khavari PA (2004) Mek1 alters epidermal growth and differentiation. Cancer Research 64:6035-6040.